Pathogenic Organelles Tier List — Best Synergy Picks
This tier list is an editorial recommendation, not a developer ranking. Pathogenic balance changes regularly, so the useful question is whether an organelle can define or reliably support a build, not whether an old damage number is permanently best.
What you need to know
S tier — build-defining cores
Metabolic Mitochondrion earns a top slot because official material describes its loot-to-overcharge mechanic, and developer community showcases have highlighted metabolic feedback-loop builds.
Magnetosome is also a build-shaping utility piece: official updates expanded it so attracted projectiles pierce enemies, later pass through walls, and work with beam weapons.
- Metabolic Mitochondrion — sustain / overcharge core
- Magnetosome — projectile and beam utility core
A tier — strong synergy pieces
Conductive Cnidocyst has a clear multi-target role because it binds enemies together and makes linked enemies share damage. Galvanic Sac automatically discharges energy to nearby enemies and later received an activation-range buff.
Resonant Cavity has repeatedly appeared in official balance notes around attack-speed behavior, making it meaningful but patch-sensitive.
- Conductive Cnidocyst
- Galvanic Sac
- Resonant Cavity
B tier — build dependent
Golgi Apparatus transfers connected melee attacks to connected projectile attacks, which can be powerful in the right network but depends heavily on layout. Sentry Polyp spawns turrets, so its value depends on whether the rest of the build supports summoned firepower.
- Golgi Apparatus
- Sentry Polyp
Unranked pending live tooltip verification
Vesicle is a confirmed internal organelle from the More Firepower update, but the public introduction note does not publish its complete live tooltip. This site does not invent the missing effect or numerical values.
Common questions
Is this an official Pathogenic tier list?
No. The tiers are editorial recommendations built around official mechanics and public balance notes.
Why is Vesicle unranked?
Its existence is officially confirmed, but the public introduction note does not provide enough current effect detail for a responsible ranking.
Source notes
Mechanics on this page are limited to the linked official or developer-published material. Editorial build advice is labeled as guidance rather than developer ranking.