Mechanics & Systems
Evolution preview, daily challenges, plasmids, difficulty settings, and pickup rules explained from official update notes.
Pathogenic Evolution Preview — Test Layouts Before Evolving
Pathogenic’s evolution preview lets you test different organelle builds before confirming. Learn what the official update changed and how to use the preview safely.
Pathogenic Daily Challenges — Seeded Runs & Random Conditions
Pathogenic Daily Challenges use random parasites, plasmids, and antibiotics with seeded runs for repeat practice. Learn the verified rules and difficulty context.
Pathogenic Plasmids Guide — Skill Trees & Shared Level Cap
Understand Pathogenic plasmid progression using official notes on pathogen-specific skill trees, cheaper upgrades, the shared plasmid level cap, and demo progress transfer.
Pathogenic Difficulty Customization — Health & Heart Drops
Pathogenic difficulty customization can adjust enemy health and heart drop rates, with an option tied to the Stomach death zone. Learn the verified settings scope.
Pathogenic Organelle Pickups — Cancel Before Equipping
Learn when Pathogenic lets you cancel an organelle reward, why mutation rewards are different, and how the pickup rule helps protect focused builds.